Where geography meets toxicology
We are a One Health toxicology research group exploring how real-world environments shape health. By combining geospatial exposure science, high-throughput biology, and computational modeling, we work to understand how environmental chemicals and mixtures influence biological responses across cells, organisms, and communities.
Our goal is to advance precision environmental health by revealing where risks are greatest and how science can support more effective prevention and protection.
Research Focus
Our research examines three interconnected dimensions of environmental health:
Chemical mixtures in the real world
Identifying location-specific exposure patterns and evaluating mixture effects through complementary computational and experimental approaches.`
Susceptibility and variability
Understanding how biological differences, including metabolic variation in CYP450 pathways, influence internal dose and toxicological response.
Cumulative stressors
Integrating chemical exposures with social and environmental stressors to reveal disproportionate disease burden and guide place-based public health action.
Approach
We combine:
- Spatial data science and GIS to map exposures, outcomes, and environmental hotspots
- High-throughput biological profiling (including phenotypic profiling) to measure cellular response
- Computational modeling and systems toxicology to connect exposures and mixtures with mechanistic pathways and adverse outcomes
- Translational integration from cell to community to inform environmental risk assessment and prevention
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